Acinus pancreas

Acini and Centro-acinar Cells. The exocrine pancreas is a compound gland consisting of secretory endpieces acini draining acinus pancreas a converging duct system [5,17,30].

A pancreatic acinus is a functional unit of the exocrine pancreas producing digest enzymes. Its pathobiology is crucial to pancreatic diseases including pancreatitis and pancreatic cancer, which can initiate from pancreatic acini. However, research on pancreatic acini has been significantly hampered due to the difficulty of culturing normal acinar cells in vitro. In this study, an in vitro model of the normal acinus, named pancreatic acinus-on-chip PAC , is developed using reprogrammed pancreatic cancer cells. In this model, human pancreatic cancer cells, Panc-1, reprogrammed to revert to the normal state upon induction of PTF1a gene expression, are cultured. Bioinformatic analyses suggest that, upon induced PTF1a expression, Panc-1 cells transition into a more normal and differentiated acinar phenotype.

Acinus pancreas

Acinar cell carcinoma of the pancreas , also acinar cell carcinoma , is a rare malignant exocrine tumour of the pancreas. It typically has a guarded prognosis. The disease is more common in men than women and the average age at diagnosis is about ACC is associated with increased serum lipase and manifests in the classic presentation known as the Schmid triad subcutaneous fat necrosis , polyarthritis, eosinophilia. ACC are typically large, up to 10 cm, and soft compared to pancreatic adenocarcinoma, lacking its dense stroma. They can arise in any part of the pancreas. Histomorphologically, the tumour resembles the cells of the pancreatic acini and, typically, have moderate granular cytoplasm that stain with both PAS and PASD. Light microscopy of an acinar cell carcinoma biopsy typically shows granular appearance. ACC can be treated with a Whipple procedure or depending on the location within the pancreas with left partial resection of pancreas. Contents move to sidebar hide. Article Talk. Read Edit View history. Tools Tools. Download as PDF Printable version. In other projects.

Biotinylated secondary acinus pancreas 1 : was added and incubated for 20 minutes at room temperature. Nadelhaft I, Biophys.

The pancreatic acinar cell is the functional unit of the exocrine pancreas. It synthesizes, stores, and secretes digestive enzymes. Under normal physiological conditions, digestive enzymes are activated only once they have reached the duodenum. Premature activation of these enzymes within pancreatic acinar cells leads to the onset of acute pancreatitis; it is the major clinical disorder associated with pancreatic acinar cells. Although there have been major advances in our understanding of the pathogenesis of this disease in recent years, available treatment options are still limited to traditional nonspecific and palliative interventions. Novel therapeutic strategies have been suggested based on ongoing research in the physiology and pathophysiology of the disease; these include the administration of systemic antibiotics, antioxidants, cytokine antagonists, and more recently, inhibition of the renin-angiotensin system.

The berry-shaped termination of an exocrine gland , where the secretion is produced, is acinar in form, as is the alveolar sac containing multiple alveoli in the lungs. The thyroid follicles can also be considered of acinar formation but in this case the follicles, being part of an endocrine gland, act as a hormonal deposit rather than to facilitate secretion. Mucous acini usually stain pale, while serous acini usually stain dark. The end of the terminal bronchioles in the lungs mark the beginning of a pulmonary acinus that includes the respiratory bronchioles , alveolar ducts, alveolar sacs, and alveoli. This anatomy article is a stub. You can help Wikipedia by expanding it. Contents move to sidebar hide.

Acinus pancreas

Federal government websites often end in. The site is secure. Preview improvements coming to the PMC website in October Learn More or Try it out now. This review focuses on studies from the past year that have greatly advanced our understanding of molecular and cellular regulation of pancreatic acinar cell function. Recent advances focus on signals dictating pancreatic development, acinar cell fate, pancreatic growth, and secretion. Regeneration of acinar cells after pancreatitis depends on expression of embryonic signals in mature acinar cells. In this setting, acinar cells can also transdifferentiate into adipose cells.

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J Gen Physiol — In this model, human pancreatic cancer cells, Panc-1, reprogrammed to revert to the normal state upon induction of PTF1a gene expression, are cultured. Footnotes Conflicts of interest The authors declare no conflicts of interest. Moreover, it is challenging to interpret the end results to establish a mechanistic understanding due to the lack of precise control of the microenvironmental conditions. Function of the Exocrine Pancreas. Oncol , , 12 , — A pancreatic acinus is a functional unit of the exocrine pancreas producing digest enzymes. Several techniques have been developed and used to create a tubular lumen structure including 3D printing using sacrificial structures 43 , 44 or pattern a gel by viscous fingering 19 , 20 , 45 or using rods. The acinar cell is highly polarized, so that the nucleus is typically located near the basal side, as noted in histology Fig. For PDAC research, these small animal models include mouse xenograft and allograft heterotopic and orthotopic models, as well as genetically engineered mouse models GEMMs. This feature is very useful to study the effects of risk factors of pancreatic cancers, in which prolonged exposure of environmental chemicals and carcinogens on the normal pancreas should be monitored. Categories : Digestive system neoplasia Pancreas disorders Pancreatic cancer. This implies a therapeutic potential of PTF1a. Discussion The PAC model addresses one of the key technical challenges to microfabricate acinus geometry, a 3D cavity of the enlarged lumen. This engineered cell line still maintains cancer-like properties, but PTF1a can be induced using the tetracycline derivative doxycycline Dox.

The pancreas is an abdominal organ located deep in the retroperitoneum.

A small outlet hole is then created with a needle to allow the flow of fluid through the channel. First published 09 Aug Under normal physiological conditions, digestive enzymes are activated only once they have reached the duodenum. Novak I, Greger R Properties of the luminal membrane of isolated perfused rat pancreatic ducts. It typically has a guarded prognosis. Bioinformatic analysis is performed to confirm the phenotypic changes upon PTF1a induction. This will create a duct structure, as reported previously. Tax calculation will be finalised at checkout Purchases are for personal use only Learn about institutional subscriptions. In: Burnstock G ed The autonomic nervous system, vol 6. ACC is associated with increased serum lipase and manifests in the classic presentation known as the Schmid triad subcutaneous fat necrosis , polyarthritis, eosinophilia. The structure of the collagen matrix surrounding the cells by second harmonic generation microscopy is compared in Fig. Samples were fixed in 2.