Alpha inhibin

Inhibin is a peptide hormone alpha inhibin is produced by ovarian granulosa cells which inhibits the release of Follicle-Stimulating Hormone FSH. The Inhibin alpha antibody subunit is expressed in a wide range of human tissues outside the reproductive axis such as prostate, brain, adrenal, as well as in the granulosa cells of the ovary, Sertoli cells of brahmin handbags testis and various cells of the fetoplacental unit, alpha inhibin.

It appears that your browser has cookies disabled. The website requires your browser to enable cookies in order to login. Don't have a login? Register today to view list prices and apply for an account to purchase online! Inhibins and activins play a role in the regulation of pituitary follicle stimulating hormone FSH secretion. The actions of inhibins and activins are thought to oppose one another, with inhibins suppressing FSH secretion and activins stimulating FSH secretion. Inhibins are secreted by granulosa cells in female follicles and Sertoli cells of the testis in the male.

Alpha inhibin

Click here to buy online! Inhibins are peptide hormones produced by the granulosa cells in female follicles and by Sertoli cells in the male seminiferous tubules. They are selectively expressed by cells of sex-cord stromal derivation, and inhibit the secretion of follitropin by the pituitary gland. Inhibin contains an alpha and beta subunit linked by disulfide bonds. Two forms of inhibin differ in their beta subunits A or B , while their alpha subunits are identical. Inhibin belongs to the transforming growth factor-beta TGF-beta family. Sex-Cord Stromal Tumors of the Ovary as well as Trophoblastic Tumors also demonstrate cytoplasmic positivity with this antibody. Availability Catalog No. Skip to content. Facebook page opens in new window Twitter page opens in new window Instagram page opens in new window. Inhibin Alpha R1 , MMab. United States.

Answer C is incorrect as granulosa cell tumors will stain strongly for inhibin; however, alpha inhibin, they typically show minimal staining for reticulin. Lost your password?

Federal government websites often end in. The site is secure. As a result of its expression in corresponding normal cell types, inhibin alpha INHA is used as an immunohistochemical marker for adrenocortical neoplasms and testicular or ovarian sex cord stromal tumors. However, other tumors can also express INHA. To comprehensively determine INHA expression in cancer, a tissue microarray containing 15, samples from different tumor types and subtypes was analyzed by immunohistochemistry. In summary, these data support the use of INHA antibodies for detecting sex cord stromal tumors, granular cell tumors, and adrenocortical neoplasms. Since INHA can also be found in other tumor entities, INHA immunohistochemistry should only be considered as a part of any panel for the distinction of tumor entities.

It appears that your browser has cookies disabled. The website requires your browser to enable cookies in order to login. Don't have a login? Register today to view list prices and apply for an account to purchase online! Inhibins and activins play a role in the regulation of pituitary follicle stimulating hormone FSH secretion.

Alpha inhibin

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Data Availability Statement All data generated or analyzed during this study are included in this published article. Freshly cut TMA sections were immunostained on one day and in one experiment. Answers B, C and D are incorrect because inhibin staining is most often negative in soft tissue neoplasms like liposarcomas, schwannomas and neurofibromas and may only be useful as part of an antibody panel in very limited cases. Inhibin alpha is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7. Open in a separate window. Essential features. This was independent of the tumor type. Dimeric glycoprotein consisting of alpha and beta subunits that is mainly produced in the gonads Regulates follicle stimulating hormone FSH secretion through negative feedback mechanisms with paracrine and autocrine actions on gonads and adrenal glands. Limited Stock More Details. Availability Catalog No.

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Mirlacher M. The authors also show RNA data indicating a poor clinical outcome of INHA-positive tumors in ovarian cancers and renal cell carcinomas [ 44 ]. To ensure as broad as possible a range of proteins to be tested for possible cross-reactivity, 76 different normal tissue categories were included in this analysis. A Iczkowski K. Using MSVAR, significant cytoplasmic staining is seen in adrenocortical cells A , Sertoli and Leydig cells of the testis B , the corpus luteum C and theca cells D of the ovary, decidua cells in the pregnant uterus E , and in trophoblast cells of the first trimester placenta F. Product is limited in stock. Histologic characteristics of thecomas are poorly defined cytoplasmic membranes with a pale gray cytoplasm. Federal government websites often end in. For raw data and references, see Table S1. Limited Stock More Details. Survival curves were calculated according to Kaplan—Meier. Tumors of the lung, pleura, and thymus. Product is out of stock. Zhang P. Contributed by Pamela Wirth, Ph.