Dehydratase

Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up dehydratase date browser or turn off compatibility mode in Internet Explorer, dehydratase.

Federal government websites often end in. The site is secure. Lead poisoning affects many organs in the body. Our meta-analysis studied the effects of the ALAD polymorphism on a blood and bone lead levels and b indicators of target organ toxicity. Sample sizes, means, and standard deviations were extracted for the genotype groups. There was a statistically significant association between ALAD2 carriers and higher BLL in lead-exposed workers weighted mean differences of 1.

Dehydratase

Dehydratases are a group of lyase enzymes that form double and triple bonds in a substrate through the removal of water. Dehydratases can act on hydroxyacyl-CoA with or without cofactors , and some have a metal and non-metal cluster act as their active site. A dehydratase deficiency in the body can lead to a less severe condition of hyperphenylalaninemia , which involves an over presence of phenylalanine in the blood. It is caused by a genetic recessive disorder in the autosomal DNA. This enzyme -related article is a stub. You can help Wikipedia by expanding it. Contents move to sidebar hide. Article Talk. Read Edit View history. Tools Tools. Download as PDF Printable version. Group of lyase enzymes. The Free Dictionary. Retrieved Genetics Home Reference.

Differences in lead accumulation in various bone types have been reported, dehydratase. Race Authors Asha V. Moreover, the role of other genes such as VDR could alter dehydratase deposition in bone.

Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Complex polyketides of bacterial origin are biosynthesised by giant assembly-line like megaenzymes of the type 1 modular polyketide synthase PKS class.

Coenzyme B 12 -dependent glycerol dehydratase GDHt catalyzes the dehydration reaction of glycerol in the presence of adenosylcobalamin to yield 3-hydroxypropanal 3-HPA , which can be converted biologically to versatile platform chemicals such as 1,3-propanediol and 3-hydroxypropionic acid. Owing to the increased demand for biofuels, developing biological processes based on glycerol, which is a byproduct of biodiesel production, has attracted considerable attention recently. In this review, we will provide updates on the current understanding of the catalytic mechanism and structure of coenzyme B 12 -dependent GDHt, and then summarize the results of engineering attempts, with perspectives on future directions in its engineering. In addition, 3-HPA has an inhibitory effect on the growth of a wide variety of bacteria and therefore, prevents food spoilage, making it a suitable food preservative Vollenweider and Lacroix, In particular, owing to the increase in the demand for biofuels, biological processes based on glycerol, a byproduct of biodiesel production, have been a recent focus of research Da Silva et al. Besides glycerol, GDHt is also involved in the dehydration reaction of 1,2-propanediol to produce propanal, and the dehydration of 2,3-butanediol to yield butanone Toraya et al.

Dehydratase

Federal government websites often end in. Before sharing sensitive information, make sure you're on a federal government site. The site is secure. NCBI Bookshelf. Gaurav Mohan ; Ankit Madan. Authors Gaurav Mohan 1 ; Ankit Madan 2. ALA dehydratase porphyria is an extremely rare type of acute porphyria that follows a chronic course punctuated by acute attacks. To avoid multiple relapses, the disease must be diagnosed early and triggers must be addressed and avoided.

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Figure 4. ALAD polymorphism and blood lead level. The trans -AT family of modular PKSs, whose biosynthetic frameworks diverge significantly from those of the archetypal cis -AT type systems represent a new paradigm in natural product enzymology. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. This interface is predominantly formed by residues from the larger-sized N-terminal domain. The oligomeric state of PksH observed in the crystal structure is consistent with our hydrodynamic analyses that suggest that this enzyme is trimeric both in solution and in crystallo Fig. Reprints and permissions. The vitamin D endocrine system plays an essential role in calcium homeostasis and bone metabolism. The product formation was measured using the thiobarbituric acid TBA assay Categories : Hydrogen biology Enzyme stubs. These megasynthases possess a distinctive assembly-line like architecture comprised of linearly arranged multi-domain extension modules, housed in sequence within giant polypeptide chains 4 , 5. Multicompartment kinetic models for lead: Part I. Our meta-analysis studied the effects of the ALAD polymorphism on a blood and bone lead levels and b indicators of target organ toxicity. Leslie, A. Progress challenges and opportunities for the re-engineering of trans -AT polyketide synthases.

Dihydroxy-acid dehydratase DHAD plays an important role in the utilization of glycerol or glucose for the production of value-added chemicals in the in vitro synthetic enzymatic biosystem. The low activity of DHAD in the dehydration of glycerate to pyruvate hampers its applications in biosystems.

Walsh, C. Reprints and permissions. The most likely binding site for the substrate is circled with a red ellipse. A detailed structural and functional characterization of these enzymes is important for understanding the catalytic mechanism and the substrate specificity, which could help improve the synthetic metabolic pathways in biorefinery industries. Additional information Publisher's note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. That is, the variant ALAD2 protein may effectively increase the blood and soft tissue e. C—N bond formation by a polyketide synthase Article Open access 10 March Retrieved Corresponding mass spectra are shown in SI. Characterization and mutagenesis of two novel iron-sulphur cluster pentonate dehydratases. Full size table. Complex polyketides of bacterial origin are biosynthesised by giant assembly-line like megaenzymes of the type 1 modular polyketide synthase PKS class. Identification and characterization of L-arabonate dehydratase, Lketodeoxyarabonate dehydratase, and L-arabinolactonase involved in an alternative pathway of L-arabinose metabolism. The sequence alignment is presented in Fig. Life Sci.