Durect corp

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DURECT harnesses epigenetic modulation to treat serious and life-threatening conditions, including acute organ injury and cancer. Many types of acute organ injuries and cancers are associated with dysregulation of the epigenome, such as DNA methylation. There is vast potential for epigenetic therapies to address the underlying pathophysiology by mitigating epigenomic dysregulation and helping to improve cellular function or suppress tumor growth. Join our highly experienced, talented, and collaborative team as we strive to improve the course of human medicine with novel epigenetic therapies. Brown, President and Chief.

Durect corp

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Join our highly experienced, durect corp, talented, and collaborative team as we strive to improve the course of human medicine with novel epigenetic therapies. We use cookies on our website to give you the most relevant experience by remembering durect corp preferences and repeat visits. These cookies track visitors across websites and collect information to provide customized ads.

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Compelling efficacy signal in favor of larsucosterol in the key secondary endpoint of mortality at 90 days. Numerical improvement in primary endpoint of mortality or transplant at 90 days did not achieve statistical significance. More pronounced effect in the U. Larsucosterol was well-tolerated and both 30 mg and 90 mg dose groups had numerically fewer adverse events than SOC. Strong rationale for advancing larsucosterol in a Phase 3 registration trial in alcohol-associated hepatitis with reduction in day mortality as the primary endpoint. ET today. The numerical improvement in the primary endpoint of mortality or transplant at 90 days did not achieve statistical significance for either dose of larsucosterol. Both doses of larsucosterol showed a more pronounced reduction in mortality in patients enrolled in the U. Larsucosterol was safe and well tolerated.

Durect corp

Brown , D. We look forward to entering discussions with the U. We also plan to discuss the design of a potential registrational Phase 3 trial using mortality as the primary endpoint. Current treatment with steroids has only marginal short-term benefits and no effect on longer term mortality.

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You can manage and withdraw your consent at any time using our cookie consent tool found here in Cookie Settings. Join Our Team. Out of these cookies, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. There is vast potential for epigenetic therapies to address the underlying pathophysiology by mitigating epigenomic dysregulation and helping to improve cellular function or suppress tumor growth. The cookies is used to store the user consent for the cookies in the category "Necessary". You also have the option to opt-out of these cookies. Open 0. The cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. The cookie is used to store the user consent for the cookies in the category "Analytics". This cookie is set by Rubicon Project to control synchronization of user identification and exchange of user data between various ad services. The emerging role of epigenetics in human autoimmune disorders.

DURECT harnesses epigenetic modulation to treat serious and life-threatening conditions, including acute organ injury and cancer. Many types of acute organ injuries and cancers are associated with dysregulation of the epigenome, such as DNA methylation.

MediaMath sets this cookie to avoid the same ads from being shown repeatedly and for relevant advertising. Use our equities screener to discover other potential opportunities. Brown, President and Chief. The cookie stores information anonymously and assigns a randomly generated number to recognize unique visitors. Unlocking the potential of epigenetic therapeutics to revolutionize medicine. DURECT harnesses epigenetic modulation to treat serious and life-threatening conditions, including acute organ injury and cancer. View All Press Releases. Out of these cookies, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. You can manage and withdraw your consent at any time using our cookie consent tool found here in Cookie Settings. PLoS One. Close Privacy Overview This website uses cookies to improve your experience while you navigate through the website.