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Federal government websites often end in. The site is secure. Opioid medications are among the most effective analgesics. However, the consequences of opioid exposure to the developing human offspring are not known.

Image by Asad Amin from Pixabay. In the last several days there has been a lot of talk about videos on YouTube and YouTube Kids that are inappropriate for our children. One of those videos, the cartoon with the suicide clip, was brought to light right here on PediMom. I wish I could say that they are isolated incidents but unfortunately I cannot. My research has led me into a horrifying world where people create cartoons glorifying dangerous topics and scenarios such self-harm, suicide, sexual exploitation, trafficking, domestic violence, sexual abuse, and gun violence which includes a simulated school shooting. All of these videos were found on YouTube Kids, a platform that advertises itself to be a safe place for children 8 years old and under. All of the following videos and screenshots are from YouTube Kids specifically and all were found by me just today.

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These problems occur in about 1 in every 1, newborn babies each year. Spina bifida. Babies born with spina bifida may have minor or short-term problems. Or they may have lasting, serious physical problems. These may include paralysis, lack of bowel and bladder control, club feet, a buildup of spinal fluid in the head hydrocephaly , and intellectual disability. In most cases, a child may need surgery before or after birth. This is the most common kind of ONTD. Babies with anencephaly often die in the uterus after 20 weeks of pregnancy stillborn. Or they only live for a very short time after birth. This is a very rare condition. With this defect, the brain or its coverings poke through the skull. This can occur anywhere from the forehead to the lower back of the skull. But it may also occur in the front of the skull, near the nose and sinuses.

With this defect, the brain or its coverings poke through the skull. All analyses were performed using SAS 9.

Federal government websites often end in. The site is secure. Neural tube defects NTDs are common complex congenital malformations resulting from failure of the neural tube closure during embryogenesis. It is established that folic acid supplementation decreases the prevalence of NTDs, which has led to national public health policies regarding folic acid. However, several lines of evidence suggest that not only folates but also choline, B12 and methylation metabolisms are involved in NTDs. Decreased B12 vitamin and increased total choline or homocysteine in maternal blood have been shown to be associated with increased NTDs risk. Several polymorphisms of genes involved in these pathways have also been implicated in risk of development of NTDs.

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Sequence analysis of the coding region of human methionine synthase: Relevance to hyperhomocysteinaemia in neural-tube defects and vascular disease. Altern Med Rev. J Obstet Gynaecol Can. Mothers of offsprings with neural tube defects reported more opioid use during the periconceptional period 3. This article is more than 2 months old. The DHFR bp deletion allele thus interferes with folate metabolism and the transport of reduced folate across the placenta. Only study center met the criterion for confounding and was included in the final model; of note, folic acid did not confound our associations although folic acid has been found to reduce the risk of spina bifida. Reported opioid use in the periconceptional period by indication, Birth Defects Study, — Mice lacking the folic acid-binding protein Folbp1 are defective in early embryonic development. Infants born preterm are at risk of short-term respiratory, gastrointestinal, immunologic, and central nervous system complications, as well as long-term motor, cognitive, and neurobehavioral sequelae. Table 3 Associations between opioid medications and neural tube defects, Birth Defects Study, —

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Rampersaud E. There has to be a better way to assure this type of content is not being seen by our children. Liu S. You will face difficult decisions about how to care for your baby. This study also points out a greater reduction in NTD risk in areas with high baseline rates. The in vitro treatment of mouse embryos with choline uptake or choline metabolism inhibitors was responsible for developmental defects affecting the neural tube and the face [ ]. Fetal neural tube stem cells from Pax3 mutant mice proliferate, differentiate, and form synaptic connections when stimulated with folic acid. Know why a new medicine or treatment is prescribed and how it will help your child. Author manuscript; available in PMC Sep 2. Behunova J. Med J Aust. Oral clefts and cardiac defects. In the last several days there has been a lot of talk about videos on YouTube and YouTube Kids that are inappropriate for our children. Whitehead et al.