Gcvh

H Multiple mitochondrial dysfunctions syndrome. MLEU:

High-resolution three-dimensional structures of essential Mycobacterium tuberculosis Mtb proteins provide templates for TB drug design, but are available for only a small fraction of the Mtb proteome. Here we evaluate an intra-genus "homolog-rescue" strategy to increase the structural information available for TB drug discovery by using mycobacterial homologs with conserved active sites. Of potential TB drug targets selected for x-ray structure determination, only 16 yielded a crystal structure. By adding homologs from nine other mycobacterial species to the pipeline, structures representing an additional 52 otherwise intractable targets were solved. To determine whether these homolog structures would be useful surrogates in TB drug design, we compared the active sites of pairs of Mtb and non-TB mycobacterial NTM enzyme homologs with experimentally determined structures, using three metrics of active site similarity, including superposition of continuous pharmacophoric property distributions. The utility of these structures in TB drug design can be tested by designing inhibitors using the homolog structure and assaying the cognate Mtb enzyme; a promising test case, Mtb cytidylate kinase, is described.

Gcvh

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Federal government websites often end in. The site is secure. Streptomyces griseus contains gcvP and the gcvT-gcvH operon, which encode three intrinsic components of the GCV system. Furthermore, by an in-line probing assay, we confirmed that glycine bound directly to the putative riboswitch RNAs. These results indicate that the S. Like the wild-type strain, all mutants grew vigorously in a medium containing 0. However, the mutants showed severely restricted growth in a medium containing 0. This indicates that glycine has a growth-inhibitory effect and that the GCV system plays a critical role in glycine detoxification in S. The inhibition of bacterial growth by glycine is well established 1 , — 3 , and the cell wall is the main target of glycine action 4. Glycine is incorporated instead of alanine into peptidoglycan precursors 5 , 6 , and eventually into peptidoglycan 4.

Gcvh

PCC substr. Jiyao W et al. Conserved Protein Domain Family gcvH.

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BDI: AGRG: TNL: ESN: AGB: CCAV: CSIN: OBB: SSTN: SOE: PCHN: AHF:

Glycine cleavage complex H protein GcvH is one of the four components that form the glycine cleavage complex GCS , essential for the synthesis of C 1 one-carbon units for cell metabolism, by the oxidative cleavage of glycine.

DQU: PTET: gcsha gcshb. PXU: CRG: ADU: CSV: FVE: By adding homologs from nine other mycobacterial species to the pipeline, structures representing an additional 52 otherwise intractable targets were solved. MCAF: CHAR: gcshb gcsha. PFUC: RPHI: CIT: MPHA: OLG: