Granulosa

Adult ovarian granulosa cell tumours OCGT are interesting due to their unpredictable behaviour and capacity to produce hormones, which may cause alterations in other organs of the genital tract, granulosa.

Federal government websites often end in. The site is secure. Preview improvements coming to the PMC website in October Learn More or Try it out now. The main consequence of delaying motherhood is compromising a woman's reproductive life with a decline in fertility. A critical step in assisted human reproduction is the evaluation of the quality of oocytes and embryos before embryo transfer, and age is a predominant factor in that capacity.

Granulosa

A rare malignant sex cord stromal tumor of ovary arising from the granulosa cells of the ovary, which occurs in peri and post menopausal women, and that presents with abnormal vaginal bleeding, abdominal pain and distension. The tumor is frequently unilateral, estrogen secreting, and has a slow natural history and a tendency to relapse long after the initial diagnosis. Classification level: Disorder. Prevalence: -. ICD C ICD 2C UMLS: C MeSH: D Disease name. Gene name or symbol. Other search option s Alphabetical list. Malignant granulosa cell tumor of the ovary Suggest an update. Your message has been sent Your message has not been sent. Please contact an administrator. Comment Form X.

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Federal government websites often end in. The site is secure. Preview improvements coming to the PMC website in October Learn More or Try it out now. The ovarian follicle is the basic functional unit of the ovary, comprising theca cells and granulosa cells GCs. Mural GCs produce oestrogen during the follicular phase and progesterone after ovulation, while CCs surround the oocyte tightly and form the cumulus oophurus and corona radiata inner cell layer. However, the function of both GCs and CCs is dependent on proper follicular angiogenesis.

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Granulosa

For the best browsing experience please enable JavaScript. Instructions for Microsoft Edge and Internet Explorer , other browsers. There are different types of ovarian sex cord stromal tumours SCSTs. These can be non cancerous benign or cancerous malignant. Granulosa cell tumours are the most common type.

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A prospective study of inhibin in granulosa cell tumors of the ovary. This case, and the literature relevant to the clinical characteristics and epidemiology of these tumours is discussed in this article. Altaras, Y. Papageorgiou, D. Preview improvements coming to the PMC website in October Microtubule-containing TZPs are assumed to be involved in paracrine communication, whereas actin-containing TZPs appear to mediate gap junctional communication and CC—oocyte adhesion. Cahir, H. Ginekol Pol, 72 , pp. Vascular endothelial growth factor stimulates the primary to secondary follicle transition in bovine follicles in vitro. Pathogenesis and pathophysiology of ovarian follicular cysts in mammals. Oocytes stimulate proliferation of CCs and secrete paracrine factors, which inhibit LH receptors and progesterone production in CCs [ , , ].

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Bjorkholm, C. Jobling, et al. Robert Z. Arbogast, G. Yamashita H. After the transfection of human ovarian GCs with pre-miRa, there was an increase in the occurrence of apoptosis, probably due to a decrease in the X-linked inhibitor of apoptosis protein XIAP and caspase-3 levels [ 87 ]. In addition, intraovarian injection of an inhibitor of PDGF receptor activity caused a significant decrease in corpora lutea in rats [ 74 ]. Findlay J. As previously mentioned, GDF-9 belongs to the oocyte-secreted factors. Ghatage, J. Furthermore, overexpression of miRb resulted in increased GC and CC proliferation, whereas its inhibition during oocyte in vitro maturation caused reduction in the first polar body extrusion, mitochondrial activity and number of oocytes reaching metaphase II. Ovarian stem cells—resolving controversies. Cell Rep. Schumer, S.