Hgjv

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Hgjv

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Hgjv

Hemojuvelin HJV , also known as repulsive guidance molecule C RGMc or hemochromatosis type 2 protein HFE2 , is a membrane-bound and soluble protein in mammals that is responsible for the iron overload condition known as juvenile hemochromatosis in humans, a severe form of hemochromatosis. In humans, the hemojuvelin protein is encoded by the HFE2 gene. For many years the signal transduction pathways that regulate systemic iron homeostasis have been unknown. However it has been demonstrated that hemojuvelin interacts with bone morphogenetic protein BMP , possibly as a co-receptor, and may signal via the SMAD pathway to regulate hepcidin expression. Hepcidin levels in the liver are dramatically depressed in these knockout animals. A soluble form of HJV may be a molecule that suppresses hepcidin expression. RGMs may play inhibitory roles in prostate cancer by suppressing cell growth, adhesion, migration and invasion. The perturbed expression was associated with disease progression and poor prognosis.

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