J exp med

Potential mechanisms driving obesity-related inflammation, primarily in adipose tissue and other metabolic organs and implications of circulatory inflammatory factors on various metabolic and regulatory organs. Chromosome 15 15q abnormality in patients with Prader-Willi j exp med and Angelman syndrome. WJEM accepts both solicited and unsolicited manuscripts. Articles published in WJEM are high-quality, clinical and basic, influential research articles by established academic authors as well as new researchers.

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J exp med

Journal of Experimental Medicine is a monthly peer-reviewed medical journal published by Rockefeller University Press that publishes research papers and commentaries on the physiological , pathological , and molecular mechanisms that encompass the host response to disease. The journal prioritizes studies on intact organisms and has made a commitment to publishing studies on human subjects. The journal has no single editor-in-chief , but thirteen academic editors. Welch , the school's founder and also the first president of the Board of Scientific Directors of the Rockefeller Institute since renamed Rockefeller University. From its inception, Welch edited the journal by himself—even editing manuscripts while attending baseball games. By March , the editorial burden became too great for Welch, who stopped publishing papers and began stockpiling manuscripts and unanswered correspondence in his office, explaining the conspicuous absence of published papers from to In October , Welch appealed to the board of the Rockefeller Institute to take over the journal. The transfer of ownership and publication responsibilities required the physical transfer of manuscripts from Welch's office, which fell to the director of the Rockefeller Institute, Simon Flexner , who carried the abandoned manuscripts from Baltimore to New York City in a suitcase. The first issue published by the Rockefeller Institute appeared in February , with Flexner serving as editor, and the journal has been published regularly since then. Although the journal was adopted by the Rockefeller Institute as a venue for publication of the institute's own research, it also accepted submissions from outside. Even in the early years, more than half of the papers published in the journal came from external labs. An online archive of articles back to is available in text and PDF formats material from and earlier is only available in PDF. Material over six months old is freely accessible and access to all papers is also provided free of charge to developing countries. All content is also deposited in PubMed Central , where it is available to the public six months after publication.

From its inception, Welch edited the journal j exp med himself—even editing manuscripts while attending baseball games. Journal of Experimental Medicine is a monthly peer-reviewed medical journal published by Rockefeller University Press that publishes research papers and commentaries on the physiologicalpathologicaland molecular mechanisms that encompass the host response to disease.

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Journal of Experimental Medicine JEM is a broad journal that publishes papers providing novel conceptual insight into immunology, cancer biology, vascular biology, microbial pathogenesis, neuroscience, and stem cell biology. We are interested in original findings on all aspects of disease pathogenesis, and we are happy to consider papers reporting novel therapeutic approaches. We strongly encourage submissions of human studies. To warrant publication in JEM, a manuscript must provide novel research findings of broad interest and clear in vivo relevance. Biomedical studies immediately relevant to disease will receive high priority. Articles present comprehensive studies providing novel and significant insight into an area of interest to our general readership.

J exp med

Over the past decade, our view of human-associated microbes has expanded beyond that of a few species toward an appreciation of the diverse and niche-specialized microbial communities that develop in the human host with chronological age. The largest reservoir of microbes exists in the distal gastrointestinal tract, both in the lumen, where microbes facilitate primary and secondary metabolism, and on mucosal surfaces, where they interact with host immune cell populations. While local microbial-driven immunomodulation in the gut is well described, more recent studies have demonstrated a role for the gut microbiome in influencing remote organs and mucosal and hematopoietic immune function. Unsurprisingly, therefore, perturbation to the composition and function of the gut microbiota has been associated with chronic diseases ranging from gastrointestinal inflammatory and metabolic conditions to neurological, cardiovascular, and respiratory illnesses. Considerable effort is currently focused on understanding the natural history of microbiome development in humans in the context of health outcomes, in parallel with improving our knowledge of microbiome-host molecular interactions. These efforts ultimately aim to develop effective approaches to rehabilitate perturbed human microbial ecosystems as a means to restore health or prevent disease. This review details the role of the gut microbiome in modulating host health with a focus on immunomodulation and discusses strategies for manipulating the gut microbiome for the management or prevention of chronic inflammatory conditions.

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Leptomeningeal metastasis LM , or spread of cancer to the cerebrospinal fluid CSF and linings of the brain, is a fatal complication of cancer. In this Review, Freret and Boire describe the anatomy of the leptomeninges and routes of cancer spread to the CSF, highlighting therapeutic opportunities. Liu et al. The peripheral activity of anti-PD-1 mAb is not fully understood. Tools Tools. By March , the editorial burden became too great for Welch, who stopped publishing papers and began stockpiling manuscripts and unanswered correspondence in his office, explaining the conspicuous absence of published papers from to Categories : Creative Commons-licensed journals Delayed open access journals Academic journals established in General medical journals Monthly journals establishments in Maryland Rockefeller University Press academic journals. The authors show that early Th2 cell differentiation is driven via prolonged T—DC macro-clustering in lymph nodes and occurs in a skin site-specific manner. Altered expression of miRa and dysregulated cytokines in systemic lupus erythematosus: Unveiling diagnostic and prognostic markers. In this issue of JEM , Boisserand et al. Accessed February 23, Lymphatic Vessels in Health and Disease Close Modal.

The intestine plays an important role in nutrient digestion and absorption, microbe defense, and hormone secretion. Although major cell types have been identified in the mouse intestinal epithelium, cell type-specific markers and functional assignments are largely unavailable for human intestine.

The Year in Experimental Medicine. Intrathecal VEGF-C pretreatment promotes lymphatic drainage of brain-derived fluids and improves neurological outcomes after ischemic stroke via reduced microglia-mediated neuroinflammation and increased BDNF signaling. The authors show that early Th2 cell differentiation is driven via prolonged T—DC macro-clustering in lymph nodes and occurs in a skin site-specific manner. The transfer of ownership and publication responsibilities required the physical transfer of manuscripts from Welch's office, which fell to the director of the Rockefeller Institute, Simon Flexner , who carried the abandoned manuscripts from Baltimore to New York City in a suitcase. March 01 Mechanism for the peripheral activity of anti-PD Meningeal lymphatics are conduits for cerebrospinal fluid drainage to lymphatics and lymph nodes in the neck. In this Review, Freret and Boire describe the anatomy of the leptomeninges and routes of cancer spread to the CSF, highlighting therapeutic opportunities. Meningeal lymphatics can influence stroke outcome. Browse All.