Macquarie university dementia research centre

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The past decades of drug development have focused on clearing amyloid or reducing its formation but unfortunately have all failed to deliver. Hence, there is an unmet need for new therapeutic avenues in dementia. The multidisciplinary team of the Dementia Research Centre works closely with medicinal chemists and international pharmaceutical industry to accelerate translation into novel therapies for these devastating diseases. To treat dementia, it is vital to first understand the processes that lead to neuronal dysfunction and brain atrophy. Here, the team of the Dementia Research Centre has made fundamental discoveries that shed new light on the causes of dementia.

Macquarie university dementia research centre

Lars graduated from the University of Ulm in Germany and completed his thesis at the University … View full profile. Yuanyuan completed a PhD in Biomedical Science in Currently a Postdoctoral Fellow at Macquarie University in the Dementia Research Centre, focusing on the pathogenesis of Alzheimer's disease and related gene-target therapy. Previously working as a researcher and lecturer at the Key Laboratory … View full profile. Seonghee worked as a postdoctoral fellow at DGIST where her work focused on investigating the pathogenic mechanism… View full profile. Andrea is a research assistant responsible for histology and tissue processing at the Dementia Research Centre, Faculty of Medicine and Health Science. Emily is currently a PhD candidate with the Dementia Research Centre focusing on inhibitory interneurons in Alzheimer's disease. She also … View full profile. Sian Genoud completed her PhD in under the supervision of Prof Kay Double at The University of Sydney where she investigated the role of biometals in neurodegenerative pathways in the Parkinson's disease brain and ALS spinal cord. After completing her undergraduate Honours year under the supervision of Prof Thomas Fath in the Neurodegeneration and Repair Unit, Holly began working as a Research Assistant within the… View full profile. She completed her PhD in Bioengineering at the Pukyung National University in the Republic of Korea, identifying and characterized genetic marker related disease resistant in fish model. She then began working a… View full profile. Magdalenas research primarily focuses on identifying, and testing novel treatments for neurodegenerative diseases, as well as utilizing specific models to better understand mechanisms underlying neur… View full profile.

The past decades of drug development have focused on clearing amyloid or reducing its formation but unfortunately have all failed to deliver. E-mail: emily. Open Access.

The DRC currently includes eight research groups. The teams at the Dementia Research Centre currently have more than 10 different therapeutic development programs at different stage of pre-clinical testing. These include small molecules, antibodies and gene therapy approaches. Most of these proprietary molecules and drug targets are based on novel discoveries of disease mechanisms made over the past decade. AAVs are particularly well suited for gene delivery into cells and living organisms, including for gene therapy in humans. Operating our own AAV core allows immediate access to this cutting-edge technology for all our research teams, accelerating multiple discovery research projects and our gene-therapy pipeline.

Research output Research output per year 67 Article 12 Review article 3 Chapter 2 Editorial 1 More 1 Preprint. Research output per year. Open Access. An overview of in vitro and in vivo techniques for characterization of intranasal protein and peptide formulations for brain targeting Wong, C. Cell-specific MAPT gene expression is preserved in neuronal and glial tau cytopathologies in progressive supranuclear palsy Forrest, S. Current concepts of mixed pathologies in neurodegenerative diseases Forrest, S. Dysregulated actin dynamics and cofilin correlate with TDP pathology in sporadic amyotrophic lateral sclerosis Jagaraj, C. Methyl donor supplementation reduces phospho-Tau, Fyn and demethylated protein phosphatase 2A levels and mitigates learning and motor deficits in a mouse model of tauopathy van Hummel, A.

Macquarie university dementia research centre

View Scopus Profile. Lars graduated from the University of Ulm in Germany and completed his thesis at the University of Zurich in Switzerland in This was followed by postdoctoral fellowships at the University of Zurich, where he studied neuronal stem cells and signalling pathways, and after moving to Australia in , at the University of Sydney, focusing on basic pathomechanisms underlying neurodegenerative diseases. After 15 years of discovery research dedicated to identifying novel mechanisms underlying neuronal dysfunction and loss in dementia, his research program has evolved to translate these findings into novel therapeutic approaches. This new work is based on a portfolio of novel compounds, proprietary tools, drug target and preclinical disease models. Current projects include;.

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E-mail: carol. Fingerprint Dive into the research topics where Dementia Research Centre is active. Clinical trials. E-mail: holly. The teams at the Dementia Research Centre currently have more than 10 different therapeutic development programs at different stage of pre-clinical testing. E-mail: janet. E-mail: sian. View all 85 research outputs. Coconut oil in Alzheimer's Disease prevention — pilot study COAD-P Phase 1 clinical trial to investigate the effects of coconut oil specifically medium-chain triglycerides on ketone body production and cognitive function for the prevention of Alzheimer's disease in healthy older adults. E-mail: liming. The team at the Dementia Research Centre has a particular interest in dementia and related disorders, brain ageing and transgenic animal models of these disorders. Research output Research output per year 67 Article 12 Review article 3 Chapter 2 Editorial 1 More 1 Preprint. Sam… View full profile. Investigating the selective regional and cellular vulnerability in these disorders and associated clinicopathological relationships is a main research focus.

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She then began working a… View full profile. Projects per year. E-mail: jiyoung. E-mail: yuanyuan. Andrea is a research assistant responsible for histology and tissue processing at the Dementia Research Centre, Faculty of Medicine and Health Science. Research teams: Delerue group Ke group Fath group. E-mail: seonghee. Most of these proprietary molecules and drug targets are based on novel discoveries of disease mechanisms made over the past decade. Participation requires initial screening to identify volunteers who are safe and suitable to take part. An overview of in vitro and in vivo techniques for characterization of intranasal protein and peptide formulations for brain targeting Wong, C. E-mail: yingying. Here, the team of the Dementia Research Centre has made fundamental discoveries that shed new light on the causes of dementia. Carol Au carol. Phase 1 clinical trial to investigate the effects of coconut oil specifically medium-chain triglycerides on ketone body production and cognitive function for the prevention of Alzheimer's disease in healthy older adults. Our research.