Maria tokuyama

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Mission Statement: As citizens of the scientific biosphere, we value representation of diverse individuals who advance science and enrich the scientific community. We welcome scientists from underrepresented backgrounds, and as a team, we are committed to reforming institutional culture and policies that perpetuate racism and exclusion in science. Lab Research: The core of our research is to understand how chronic interaction between viruses and the immune system impacts immunity at steady state and during inflammation. We study endogenous retroviruses ERVs , which are viral sequences in our genome that originated from exogenous viruses and have undergone an evolutionary arms race with the host for millions of years. We currently have multiple projects aimed at uncovering how the interaction between ERVs and the immune system impacts antiviral immunity and excessive inflammation in autoimmunity. We rely on multidisciplinary approaches and novel tools in virology, immunology, and computational genomics.

Maria tokuyama

Google Scholar. Tokuyama lab. Tokuyama has always been interested in the interaction between viruses and the immune system. As an undergrad at University of California, Irvine, she worked in an infectious disease lab that focused on HIV research and obtained her B. Tokuyama obtained her Ph. Tokuyama trained at Yale University in the Department of Immunobiology, where she became fascinated by endogenous retroviruses and established the foundation for the research that she will carry out at UBC. In the past year, Dr. The overarching goal of our lab is to identify immunological mechanisms that underlie heterogeneity in disease outcomes. Our lab seeks to understand how interactions between the immune system and the virome influence outcomes of viral infection and autoimmunity. In particular, we are focused on uncovering immunomodulatory functions of endogenous retroviruses ERVs , which are retroviral sequences that make up a large fraction of the human genome. Using clinical samples, in vivo mouse models and 2D and 3D cell cultures, we seek to uncover how endogenous viral proteins affect immune cell signaling and function in health and disease through transcriptomic, proteomic and functional assays. Furthermore, we will employ computational analysis methods to study endogenous viral elements to deepen our understanding of how these elements are regulated and their potential roles in clinical outcomes. Ultimately, our goal is to identify novel biomarkers and develop biologics that mimic beneficial ERV-immune interactions while blocking detrimental interactions to prevent and treat viral infections and chronic inflammatory diseases.

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Maria tokuyama

Since March , severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 has drastically changed our lives and has killed over four million people worldwide. Data analysis from New York City Health found that of all death cases Several research studies have shown that differences in immune response and metabolism during disease may partly explain the worse outcomes in males than females. Here, we will summarize the key takeaways from those studies. The immune system is largely divided into two parts: the innate and adaptive immune system. It is able to recognize danger within minutes and rapidly fire inflammatory factors called cytokines and chemokines to recruit immune cells to sites of infection and set off alarms to engage the adaptive immune system. The adaptive immune response takes about five to seven days to fully kick-in, but once activated, it is very specific to the invading pathogen and provides long-term memory responses that can be quickly recalled to fight future infections by the same pathogen. The adaptive arm of the immune system is what is provided by vaccinations. During viral infection, both the innate and adaptive immune responses work together to fight the infection.

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MedRxiv , Maria Tokuyama. Sign in. Add co-authors Co-authors. For more information: tokuyamalab. Support us. Google Scholar. Research Summary Open Close. Infection, Immunity, and Inflammation. We currently have multiple projects aimed at uncovering how the interaction between ERVs and the immune system impacts antiviral immunity and excessive inflammation in autoimmunity. Their combined citations are counted only for the first article. My profile My library Metrics Alerts. New articles related to this author's research.

The lab hopes to contribute towards development of immune modulators to treat infections and chronic inflammatory diseases. Tokuyama, whose excitement for scientific research actually began with a book.

PLoS Biology 18 10 , e , Faculty of Science. About MBIM. Title Sort Sort by citations Sort by year Sort by title. For more information: tokuyamalab. PloS one 3 10 , e , Associated Departments. Research Summary Open Close. Their combined citations are counted only for the first article. New articles related to this author's research. We welcome scientists from underrepresented backgrounds, and as a team, we are committed to reforming institutional culture and policies that perpetuate racism and exclusion in science. The system can't perform the operation now. Department of Microbiology and Immunology. Research Study Work Support us. The overarching goal of our lab is to identify immunological mechanisms that underlie heterogeneity in disease outcomes.