Ondansetron drug interactions

Ondansetron is a medicine used to ondansetron drug interactions nausea and vomiting caused by surgery or cancer treatments. Ondansetron works by blocking serotonin, a natural substance in the brain that can trigger nausea and vomiting.

Purpose: Both ondansetron and cyclophosphamide are thought to be metabolized by hepatic microsomal processes. The purpose of this study was to evaluate the potential pharmacokinetic interactions between ondansetron and high-dose alkylating agent chemotherapy. Methods: A total of 54 breast cancer patients receiving high-dose cyclophosphamide, cisplatin and carmustine were treated prospectively in four sequential cohorts. Cohorts I and II received continuous infusions of both ondansetron and prochlorperazine, and cohorts III and IV received a continuous infusion of ondansetron alone at the same doses. All patients received lorazepam every 4 h.

Ondansetron drug interactions

Key takeaways Drug interactions Food interactions Other interactions Avoiding interactions When to see a doctor. Ondansetron , known under the brand name Zofran , is a selective 5-HT3 receptor antagonist that functions as an antiemetic to aid in the prevention of nausea and vomiting from chemotherapy or radiation therapy , treatment of severe and acute nausea and vomiting and the prevention and treatment of postoperative nausea and vomiting. Ondansetron is available as an injection, an oral solution, an oral tablet, and an orally-disintegrating tablet. Ondansetron interactions with amiodarone, domperidone, methadone, specific antiarrhythmic and antibiotic medications, and serotonergic agents. Ondansetron can also affect the metabolism of other medicines, exacerbating side effects associated with individual drugs. The most serious medications that ondansetron interferes with include certain antiarrhythmics, antibiotics, and serotonergic medications. As a selective 5HT3 receptor antagonist , Ondansetron blocks serotonin peripherally and centrally. Therefore, combining with other medications in the 5HT3 receptor antagonist class will increase the potential risk. Monoamine oxidase inhibitors , or MAOIs, were the first class of antidepressants developed. These medications work by blocking an enzyme , monoamine oxidase, which removes serotonin from the brain. By inhibiting this enzyme , increased serotonin levels remain available to regulate, allowing feelings of focus, emotional stability, and overall happiness. Other medications inhibit monoamine oxidase as a secondary mechanism to a primary, intended effect.

Both Ondansetron and Fentanyl can increase the risk of serotonin syndrome. Absorption: Ondansetron undergoes rapid ondansetron drug interactions from the GI tract, and the peak plasma concentration Tmax is approximately 1. Do not freeze.

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In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals.

Ondansetron drug interactions

Key takeaways Drug interactions Food interactions Other interactions Avoiding interactions When to see a doctor. Ondansetron , known under the brand name Zofran , is a selective 5-HT3 receptor antagonist that functions as an antiemetic to aid in the prevention of nausea and vomiting from chemotherapy or radiation therapy , treatment of severe and acute nausea and vomiting and the prevention and treatment of postoperative nausea and vomiting. Ondansetron is available as an injection, an oral solution, an oral tablet, and an orally-disintegrating tablet. Ondansetron interactions with amiodarone, domperidone, methadone, specific antiarrhythmic and antibiotic medications, and serotonergic agents. Ondansetron can also affect the metabolism of other medicines, exacerbating side effects associated with individual drugs. The most serious medications that ondansetron interferes with include certain antiarrhythmics, antibiotics, and serotonergic medications. As a selective 5HT3 receptor antagonist , Ondansetron blocks serotonin peripherally and centrally. Therefore, combining with other medications in the 5HT3 receptor antagonist class will increase the potential risk.

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The role of CYP3A4 is important at higher concentrations of ondansetron. Interventions for treating hyperemesis gravidarum: a network meta-analysis of randomized clinical trials. If you miss a dose and feel sick or vomit, take it as soon as possible and continue with your regular schedule. It is also used to prevent and treat the nausea and vomiting that occurs after surgery. Domperidone increases the risk of QT-prolongation when given with Ondansetron. Clin Pharmacol Ther. Some dosage forms of ondansetron contain sodium benzoate, a metabolite of benzyl alcohol. Both Ondansetron and Lenvatinib prolong the QT interval. Carbamazepine is predicted to decrease the exposure to Ondansetron. Contact your doctor if you experience these side effects and they are severe or bothersome. Current evidence does not demonstrate a need to pre-screen this population before administering ondansetron for patients without any of the above risk factors. The buildup of this amino acid can result in long-term intellectual disabilities, so afflicted individuals must follow a diet that limits phenylalanine.

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Check with your doctor right away if you start to have pain or swelling in your stomach area. Combining the use of other drugs known to prolong the QTc may further increase the risk for serious side effects , with at least one study identifying the use of an additional QT-prolonging drug as the most common risk factor among patients with an identified QT prolongation. Saudi Pharm J. Appropriate studies have not been performed on the relationship of age to the effects of ondansetron in children younger than 4 years of age. Advertising Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission. Monitoring should be done in high-risk patients receiving ondansetron intravenously. The presumed mechanism for this decreased analgesic effect between these two medications is thought to involve the antagonism of spinal 5HT3 receptors by ondansetron , which is an effect in opposition to the actions of tramadol , which is suspected to exert some of its pain-relieving effects. Ondansetron is not expected to harm an unborn baby. It is also used to prevent nausea and vomiting that may occur after surgery. Affiliations 1 Medical University South Carolina. A randomised trial of ondansetron for the treatment of irritable bowel syndrome with diarrhoea. Mayo Clinic does not endorse any of the third party products and services advertised. Breastfeeding Considerations: In a pharmacokinetic study, the relative infant exposure to ondansetron is less. Ondansetron is used to prevent nausea and vomiting that is caused by cancer medicines chemotherapy or radiation therapy.