Ondansetron moa

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Ondansetron , sold under the brand name Zofran among others, is a medication used to prevent nausea and vomiting caused by cancer chemotherapy , radiation therapy , or surgery. Common side effects include diarrhea , constipation , headache , sleepiness , and itchiness. Ondansetron was patented in and approved for medical use in Ondansetron is indicated for the prevention of chemotherapy-induced nausea and vomiting and postoperative nausea and vomiting. Ondansetron is used off-label to treat morning sickness and hyperemesis gravidarum of pregnancy.

Ondansetron moa

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Official websites use. Share sensitive information only on official, secure websites. Ondansetron is used to prevent nausea and vomiting caused by cancer chemotherapy, radiation therapy, and surgery. Ondansetron is in a class of medications called serotonin 5-HT 3 receptor antagonists. It works by blocking the action of serotonin, a natural substance that may cause nausea and vomiting. Ondansetron comes as a tablet, a rapidly disintegrating dissolving tablet, film, and an oral solution liquid to take by mouth. The first dose of ondansetron is usually taken 30 minutes before the start of chemotherapy, 1 to 2 hours before the start of radiation therapy, or 1 hour before surgery.

Excipient information presented when available limited, particularly for generics ; consult specific product labeling. Ondansetron is a selective 5-HT 3 -receptor antagonist which blocks serotonin, both peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone. Surgical patients: Infants and Children: 1 to 4 months: 0. Adult normal : 19 to 40 years: 0. Surgical patients: Infants 1 to 4 months: 6. Clearance is reduced 2- to 3-fold and the volume of distribution is increased.

Ondansetron moa

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Store the tablets and rapidly disintegrating tablets away from light, at room temperature or in the refrigerator. Ondansetron is a highly potent and selective antagonist at 5-HT3 receptors. Migraine-type headaches in children receiving chemotherapy and ondansetron. Instead, the best way to dispose of your medication is through a medicine take-back program. Agonists: 4-Methylaminorex Aminorex Amphetamines e. There are limited data available from pediatric populations. Antagonists: ABT Atypical antipsychotics e. Metabolism: The liver is the primary site of metabolism. You are not required to obtain permission to distribute this article, provided that you credit the author and journal. Use in Specific Patient Populations Patients with Hepatic Impairment: No dose adjustments of ondansetron are necessary for mild to moderate hepatic impairment. Ondansetron also has effects peripherally by acting on the vagus nerve. Using ondansetron during cesarean section does not affect the onset of breastfeeding. Summarize the adverse event profile of ondansetron. Delayed diagnosis of anaphylaxis secondary to ondansetron: A case report.

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Read Edit View history. Electrolyte and electrocardiogram monitoring are suggested in patients treated with ondansetron having risk factors for arrhythmia, such as a family history of prolonged QT interval, heart failure, and electrolyte disturbances. It works by blocking the action of serotonin, a natural substance that may cause nausea and vomiting. Am J Case Rep. Ask your pharmacist any questions you have about refilling your prescription. Ondansetron also has effects peripherally by acting on the vagus nerve. Assessment of ondansetron-associated hypokalemia in pediatric oncology patients. However, it is not effective for motion sickness-induced nausea. Ondansetron was patented in and approved for medical use in StatPearls [Internet]. It is important for you to keep a written list of all of the prescription and nonprescription over-the-counter medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements.