Photys

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For our final Chat8VC of , we hosted Dr. He sits at a very compelling vantage point in this role. Photys is pioneering the use of PHICs, a new class of medicines that can control the modification of proteins and address a number of important diseases that were previously undruggable. Most small molecule drugs have historically relied on the traditional paradigm of protein inhibition, and this approach has proven to be wildly successful. Throwing a wrench in the gears of disease-related pathways has led to bestselling drugs like Lipitor and Prilosec.

Photys

JavaScript is not enabled! This website requires your browser to have JavaScript enabled. Check enable-javascript. Creative Office Resources partnered with Photys, a proprietary bifunctional small molecules platform company to assist with their new headquarters project in Waltham, MA. COR was thrilled to help them reach their goal of enhancing their brand and culture in a new space with the incorporation of furniture and color while staying within budget and on time. COR worked alongside a strong team to ensure the furniture selected would add value to the employee experience. The 20, square-foot space includes workstations, private offices, meeting rooms, lab seating and ancillary. Life Science Photys Creative Office Resources partnered with Photys, a proprietary bifunctional small molecules platform company to assist with their new headquarters project in Waltham, MA. The COR team provided great support throughout the process, from design to installation and follow ups. Jessica captured our vision right away. We were able to brainstorm ideas and designs to ultimately make our vision a reality. Steve's team of installers was incredibly efficient, on time and on schedule. The entire team here loves the space!

To obtain the best experience, photys, we recommend you use a more up to date browser or photys off compatibility mode in Internet Explorer. The 20, square-foot space includes workstations, private offices, meeting rooms, lab seating and ancillary.

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Although the drugs may be years away from clinical testing, if the approach works, it will have broad implications for many diseases. Photys Therapeutics was founded late last year to develop a technology invented by Dr. Amit Choudhary at the Broad. In August , Choudhary published a paper describing the creation of dumbbell-shaped small molecules that could be used to bring two specific proteins together. One end of the dumbbell sticks to a protein called a kinase and the other end sticks to a protein involved in disease. Sometimes that switch simply turns a protein on or off. There are dozens of cancer drugs that inhibit kinases to stop the proteins from making the chemical decorations. There are hundreds of kinases and thousands of ways that they can phosphorylate other proteins, suggesting potentially vast uses for the technology, which the startup calls phosphorylation-inducing chimeric small molecules, or PHICS. Brian Fenton, chief executive of Photys, said that cancer is a major initial focus for the company, as well as immune, metabolic, and rare diseases.

Photys

Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Phosphate groups are among the principal forms of currency in the cell, and the enzymatic addition and removal of phosphates from target proteins plays a central role in orchestrating cell signaling, catalysis and a myriad of other biological activities. By one recent estimate, drugs now in the clinic work by interfering with the various kinase enzymes responsible for protein phosphorylation, with countless others in development.

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Company Name. Airbyte today is often associated with our open source data infrastructure project and product. We think these alt-TACs represent an incredibly exciting opportunity to modulate biology broadly, and are excited to continue investing and building in this space. This website requires your browser to have JavaScript enabled. Phosphate groups are among the principal forms of currency in the cell, and the enzymatic addition and removal of phosphates from target proteins plays a central role in orchestrating cell signaling, catalysis and a myriad of other biological activities. Sign up for Nature Briefing. This allows for fine-tuned control of the machinery including localization, downregulation and upregulation, increased or decreased downstream signaling, and countless other functions. Additionally, decades-long work in phosphoproteomics has resulted in many assays to measure phosphorylation, which simplifies assay development for PHICs. UNIL is a leading international teaching and research institution, with over 5, employees and 15, students split between its Dorigny campus, JavaScript is not enabled!

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To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. Taking something as ambitious as Photys from an idea to a company requires a visionary founding team with world-class abilities in research science, translational medicine, drug development, and commercialization. Email address Sign up. Watch the interview here:. The 20, square-foot space includes workstations, private offices, meeting rooms, lab seating and ancillary. COR was thrilled to help them reach their goal of enhancing their brand and culture in a new space with the incorporation of furniture and color while staying within budget and on time. You are using a browser version with limited support for CSS. Introducing Photys Photys Therapeutics is one of the first companies to apply these principles of protein modulation through the usage of bifunctional small molecules that control the phosphorylation state of proteins. Creative Office Resources partnered with Photys, a proprietary bifunctional small molecules platform company to assist with their new headquarters project in Waltham, MA. Teaching Small Molecule Drugs New Tricks Most small molecule drugs have historically relied on the traditional paradigm of protein inhibition, and this approach has proven to be wildly successful. Search Search articles by subject, keyword or author. Access through your institution. Cofounder Dr. Thank you COR! Announcing Our Investment in Photys Therapeutics.