Purple pill for gout

Colchicine is used to prevent or treat attacks of gout also called gouty arthritis. This condition is caused by too much uric acid in the blood.

Colchicine has a narrow therapeutic index , so overdosing is a significant risk. Common side effects of colchicine include gastrointestinal upset, particularly at high doses. Colchicine, in the form of the autumn crocus Colchicum autumnale , has been used as early as BC to treat joint swelling. Colchicine is widely used in plant breeding for inducing polyploidy , where the number of chromosomes in plant cells are doubled. This frequently results in larger, hardier, faster-growing, and in general more desirable plants than the normally diploid parents.

Purple pill for gout

If you are a consumer or patient please visit this version. Patients with renal or hepatic impairment should not be given colchicine tablets in conjunction with P-gp or strong CYP3A4 inhibitors 5. In these patients, life-threatening and fatal colchicine toxicity has been reported with colchicine taken in therapeutic doses 7. The potential for drug-drug interactions must be considered prior to and during therapy. See FPI for a complete list of reported and potential interactions 2. Colchicine tablets are indicated for prophylaxis and the treatment of acute gout flares. Colchicine tablets are indicated in adults and children four years or older for treatment of familial Mediterranean fever FMF. The long-term use of colchicine is established for FMF and the prophylaxis of gout flares, but the safety and efficacy of repeat treatment for gout flares has not been evaluated. The dosing regimens for colchicine tablets are different for each indication and must be individualized. Colchicine tablets are not an analgesic medication and should not be used to treat pain from other causes. The recommended dosage of colchicine tablets for prophylaxis of gout flares for adults and adolescents older than 16 years of age is 0. The maximum recommended dose for prophylaxis of gout flares is 1.

Dermatological: alopecia, maculopapular rash, purpura, rash. In these patients, life-threatening and fatal colchicine toxicity has been reported with colchicine taken in therapeutic doses 7.

Official websites use. Share sensitive information only on official, secure websites. Colchicine is used to prevent gout attacks sudden, severe pain in one or more joints caused by abnormally high levels of a substance called uric acid in the blood in adults. Colchicine Colcrys is also used to relieve the pain of gout attacks when they occur. Colchicine Colcrys is also used to treat familial Mediterranean fever FMF; an inborn condition that causes episodes of fever, pain, and swelling of the stomach area, lungs, and joints in adults and children 4 years of age and older. Colchicine is not a pain reliever and cannot be used to treat pain that is not caused by gout or FMF.

Allopurinol treats gout , hyperuricemia the buildup of uric acid in the body , and kidney stones. It is part of a class of drugs called xanthine oxidase inhibitors and is available in the United States under the brand names Zyloprim and Lopurin. Allopurinol works by reducing the production of uric acid in the body. It is also prescribed to prevent gout attacks. Gout is a type of inflammatory arthritis that causes severe swelling and pain in one joint at a time, usually the big toe. This article covers how allopurinol treats gout, its side effects, and possible drug interactions. Allopurinol is a long-term, preventive treatment for gout. It is regularly prescribed to stop gout attacks and prevent joint damage. Gout commonly occurs because of high uric acid levels in the blood.

Purple pill for gout

Doctors usually diagnose gout based on your symptoms and the appearance of the affected joint. Tests to help diagnose gout may include:. Gout medications are available in two types and focus on two different problems. The first type helps reduce the inflammation and pain associated with gout attacks.

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Table 8. In some subjects with mild to moderate cirrhosis, the clearance of colchicine is significantly reduced and plasma half-life prolonged compared to healthy subjects. By mouth. When colchicine Colcrys is used to relieve the pain of a gout attack, one dose is usually taken at the first sign of pain and a second, smaller dose is usually taken one hour later. Drugs used for gout M About this Site. Similarly, significant increase in colchicine plasma levels is anticipated with other strong CYP3A4 inhibitors 0. Medicare also paid significantly higher costs, making this a direct money-loser for the government. Prophylaxis of Gout Flares: The most commonly reported adverse reaction in clinical trials of colchicine for the prophylaxis of gout was diarrhea. If you are a consumer or patient please visit this version. Patients with renal or hepatic impairment should not be given colchicine tablets in conjunction with P-gp or strong CYP3A4 inhibitors 5. Because clinical studies are conducted under widely varying and controlled conditions, adverse reaction rates observed in clinical studies of a drug cannot be directly compared to rates in the clinical studies of another drug and may not predict the rates observed in a broader patient population in clinical practice. In the U. Letters to Editor.

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The evidence for the efficacy of colchicine in patients with chronic gout is derived from the published literature. The third study was discontinued after an interim analysis of six of the 11 patients enrolled had completed the study; results could not be confirmed. The Old, the New, and the Rare". Colchicine patents expire in February Modern Genetic Analysis. Pelletier and J. Significant increase in colchicine plasma concentration is anticipated. No specific antidote for colchicine is known, but supportive care is used in cases of overdose. Original dose Adjusted dose 0. Table 6. This Medication Guide summarizes the most important information about colchicine tablets. Bibcode : AngCh..