Quinoxaline

A quinoxalinealso called a benzopyrazinequinoxaline, in quinoxaline chemistryis a heterocyclic compound containing a ring complex made up of a benzene ring and a pyrazine ring. It is isomeric with other naphthyridines quinoxaline quinazolinephthalazine and cinnoline. Although quinoxaline itself is mainly of academic interest, quinoxaline derivatives are used as dyes, pharmaceuticals such as vareniclineand antibiotics such as olaquindoxcarbadoxechinomycinquinoxaline, levomycin and actinoleutin. They can be formed by condensing brainerd skyward - diamines with 1,2- diketones.

Quinoxaline C8H6N2 , commonly called 1,4-diazanaphthalene, 1,4-benzodiazine, or benzopyrazine, is a very potent nitrogenous heterocyclic moiety consisting of a benzene ring fused with the pyrazine ring. A number of different methods for the synthesis of quinoxaline derivatives have been reported in the literature, but the most effective method, commonly used for the synthesis of quinoxaline analogues involves the condensation of substituted o-phenylenediamines with 1, 2- dicarbonyl compounds in the presence of different catalyst s. The presence of different types of catalysts and their concentration affects the overall yield of the product. Quinoxaline not only plays an important role as an organic reaction intermediate but also has a wide spectrum of interesting biological activities viz. Some commercially available drug molecules containing quinoxaline moiety are echinomycin as antibacterial, antineoplastic, and nucleic acid inhibitor , triostins cyclic desipeptide as an antibacterial agent , dioxidine and mequindox as antibacterial agents , carbadox controlling swine dysentery , desoxycarbadox as swine growth promoter and panadipion as hepatoprotective agent , etc.

Quinoxaline

Bioinspired ortho -quinone catalysts have been applied to oxidative synthesis of benzimidazoles, quinoxalines and benzoxazoles from primary amines in high yields under mild conditions with oxygen as the terminal oxidant. Zhang, Y. Qin, L. Zhang, S. Luo, Org. Bains, V. Singh, D. Adhikari, J. Shee, D. Panja, S. Kundu, J.

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Federal government websites often end in. The site is secure. Quinoxalines, a class of N -heterocyclic compounds, are important biological agents, and a significant amount of research activity has been directed towards this class. They have several prominent pharmacological effects like antifungal, antibacterial, antiviral, and antimicrobial. Quinoxaline derivatives have diverse therapeutic uses and have become the crucial component in drugs used to treat cancerous cells, AIDS, plant viruses, schizophrenia, certifying them a great future in medicinal chemistry. Due to the current pandemic situation caused by SARS-COVID 19, it has become essential to synthesize drugs to combat deadly pathogens bacteria, fungi, viruses for now and near future.

Quinoxaline

Quinoxaline has become a subject of extensive research due to its emergence as an important chemical moiety, demonstrating a wide range of physicochemical and biological activities. The last few decades have witnessed several publications utilizing quinoxaline scaffolds for the design and development of numerous bioactive molecules, dyes, fluorescent materials, electroluminescent materials and organic sensitizers for solar cell applications and polymeric optoelectronic materials. Therefore, to fulfill the need of the scientific community, tremendous effort has been observed in the development of newer synthetic strategies as well as novel methodologies to decorate the quinoxaline scaffold with proper functional groups. Hence, to provide an updated comprehensive account of the diverse synthetic routes to access quinoxaline as well as approaches for structural diversifications, we have attempted to document the synthetic strategies and their functionalization with possible mechanistic rationalization. This will no doubt be helpful for the readers who are anticipating a comprehensive overview on quinoxaline as well as benefitting researchers for future development. Yashwantrao and S.

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The antitumoral properties of quinoxaline compounds have been of interest. PubChem CID. Cheon, J. Shen, X. Gayakhe, I. Cambridge University Press. Yuan, K. Hu, X. Panja, S. Article Talk.

A quinoxaline , also called a benzopyrazine , in organic chemistry , is a heterocyclic compound containing a ring complex made up of a benzene ring and a pyrazine ring. It is isomeric with other naphthyridines including quinazoline , phthalazine and cinnoline. Although quinoxaline itself is mainly of academic interest, quinoxaline derivatives are used as dyes, pharmaceuticals such as varenicline , and antibiotics such as olaquindox , carbadox , echinomycin , levomycin and actinoleutin.

Y verify what is Y N? Xie, W. ISBN Chen, J. S2CID Kapdi, Org. Infobox references. Bandaru, S. Kim, C. Although quinoxaline itself is mainly of academic interest, quinoxaline derivatives are used as dyes, pharmaceuticals such as varenicline , and antibiotics such as olaquindox , carbadox , echinomycin , levomycin and actinoleutin. In other projects.