Salvia miltiorrhiza

The specific epithet miltiorrhiza means "red ochre root". Salvia miltiorrhiza compounds isolated from Salvia miltiorrhiza include salvianolic acid or salvianolic acid B[3] [4] dihydrotanshinonemiltirone[5] tanshinone Iand tanshinone IIA.

Federal government websites often end in. The site is secure. Salvia miltiorrhiza Bunge, also known as Danshen in Chinese, has been widely used to treat cardiovascular diseases CVD in China and other Asia countries. Here, we summarize literatures of the historical traditional Chinese medicine TCM interpretation of the action of Salvia miltiorrhiza, its use in current clinical trials, its main phytochemical constituents and its pharmacological findings by consulting Pubmed, China Knowledge Resource Integrated, China Science and Technology Journal, and the Web of Science Databases. Since , 39 clinical trials have been identified that used S. More than individual compounds have been isolated and characterized from S.

Salvia miltiorrhiza

Chinese Medicine volume 5 , Article number: 22 Cite this article. Metrics details. Danshen , the dried root of Salvia miltiorrhiza , is a Chinese medicine used to promote blood flow and treat vascular disease. The present article reviews the pharmacological effects of Danshen on cerebral infarction and possible interactions between Danshen and Western drugs. Danshen may reduce or prolong the development of atherosclerosis and may have anti-hypertensive and anti-platelet aggregation effects, which prevent cerebral infarction. Danshen may enhance endogenous anti-oxidative enzyme activities such as the expression of endothelial nitric oxide synthase and may scavenge oxygen free radicals. Prevention and treatment of cerebral infarction by Danshen involves multiple pathways, including anti-atherosclerosis, anti-hypertension, anti-platelet aggregation, anti-inflammatory and anti-oxidative effects. Danshen , the dried root of Salvia miltiorrhiza , is used in Chinese medicine to treat vascular disease. According to Chinese medicine theory, Danshen promotes blood flow and resolves blood stasis. Cerebral infarction is an ischemic condition of the brain including thrombosis, embolism or systemic hemodynamic hypotension. Cerebral infarction is often caused by atherosclerosis of large and small arteries. The etiology of atherosclerosis and stroke is related to inflammation and genetic factors.

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Salvia miltiorrhiza Bunge SM is a very popular medicinal plant that has been extensively applied for many years to treat various diseases, especially coronary heart diseases and cerebrovascular diseases, either alone or in combination with other Chinese plant-based medicines. Although a large number of studies on SM have been performed, they are scattered across a variety of publications. The present review is an up-to-date summary of the published scientific information about the traditional uses, chemical constituents, pharmacological effects, side effects, and drug interactions with SM, in order to lay the foundation for further investigations and better utilization of SM. SM contains diverse chemical components including diterpenoid quinones, hydrophilic phenolic acids, and essential oils. Many pharmacological studies have been done on SM during the last 30 years, focusing on the cardiovascular and cerebrovascular effects, and the antioxidative, neuroprotective, antifibrotic, anti-inflammatory, and antineoplastic activities.

Federal government websites often end in. The site is secure. Salvia miltiorrhiza Bunge S. Considering its extensive usage as a therapeutic agent for multiple diseases, there is a need to review previous research regarding its therapeutic benefits and their mechanisms. Therefore, we searched PubMed and PubMed Central for articles reporting its therapeutic effects on certain disease groups including cancers, cardiovascular, liver, and nervous system diseases. This review provides an overview of therapeutic benefits and targets of S. The findings on multi-functional properties of S. It is a deciduous perennial plant which belongs to genus Salvia of Lamiaceae family [ 2 ]. The active components of S.

Salvia miltiorrhiza

Salvia miltiorrhiza Bunge is the source species of Danshen listed in Chinese Pharmacopoeia edition. Currently, the germplasm of S. Attempts have been made to use molecular markers and DNA barcoding in evaluating the genetic diversity and species identification of medicinal Danshen materials. Different cultivation modes, such as direct seeding and root propagation, are used in different production areas in China, and the latter is more popular than the former.

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Yang P. Effects of Salvia miltiorrhiza in the Development of Artherosclerosis Atherosclerosis is a condition where the arteries become narrowed and lost of elasticity of the artey walls due to an excessive build up of sticky plaques within the arterial intima [ , ]. Significant effect: Markedly improved in clinical symptoms such as chest stuffy, palpitations, chest pain, and short of breath; Electrocardiogram ECG returned to normal. Cardiovascular diseases 40 3 weeks. Han B. Journal of Ethnopharmacology. The increases of activated microglia may represent the severity of neuronal damage in a MCAo rat model [ 38 ]. Renal angiotensin-converting enzyme and blood pressure control. Reperfusion therapy is the most effective therapeutic strategy for improving the prognosis of patients with acute myocardial infarction but accompanied with the potential risk of worsening tissue damage after ischemia [ 17 , , ]. Jin Y. Ineffective: Symptoms of heart failure and physical signs markedly improved; Cardiac function improved by more than 2 levels. Effective: Ischemic ST segment improved, but did not return to normal.

The specific epithet miltiorrhiza means "red ochre root".

The New Book of Salvias. Workman Publishing Company. Proinflammatory status, genetics and atherosclerosis. Liu Y. Significant effect: Clinical symptoms of heart failure and physical signs disappeared; Cardiac function improved by 2 levels. Protective effects of salvianolate on microvascular flow in a porcine model of myocardial ischaemia and reperfusion. A randomized placebo controlled trial of an innovative herbal formula in the prevention of atherosclerosis in postmenopausal women with borderline hypercholesterolemia. Ineffective 7. Compound Danshen dripping Pills. Although most studies reported promising efficacy in improving clinical symptoms, their significance is still need to be improved through well designed clinical trials in order to provide sufficient evidence to fully demonstrate the effects of S.