Sialic

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These examples are programmatically compiled from various online sources to illustrate current usage of the word 'sialic. Send us feedback about these examples. Accessed 14 Mar. Subscribe to America's largest dictionary and get thousands more definitions and advanced search—ad free! See Definitions and Examples ». Cite this Entry Citation Share.

Sialic

Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Emerging evidence suggests that host glycans influence severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 infection. Gangliosides embedded within an artificial membrane also bind to the RBD. RBD binding and infection of SARS-CoV-2 pseudotyped lentivirus to angiotensin-converting enzyme 2 ACE2 -expressing cells is decreased following depletion of cell surface Sia levels using three approaches: sialyltransferase ST inhibition, genetic knockout of Sia biosynthesis, or neuraminidase treatment. These effects on RBD binding and both pseudotyped and authentic SARS-CoV-2 viral entry are recapitulated with pharmacological or genetic disruption of glycolipid biosynthesis. Together, these results suggest that sialylated glycans, specifically glycolipids, facilitate viral entry of SARS-CoV Many viruses exploit carbohydrates, also known as glycans, attached to protein and lipid carriers on host epithelial cells for viral entry 1. Sialoglycans are acidic Sia-containing glycans for example, gangliosides, mucin-type O -glycans and complex N -glycans that are densely displayed on the surface of mammalian cells 2. They act as co-receptors for a wide variety of viruses, including orthomyxoviruses, paramyxoviruses, picornaviruses, reoviruses, polyomaviruses, adenoviruses, calicivirus and parvoviruses 3.

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Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Sialic acids are a family of nine-carbon acidic monosaccharides that occur naturally at the end of sugar chains attached to the surfaces of cells and soluble proteins. In the human body, the highest concentration of sialic acid as N -acetylneuraminic acid occurs in the brain where it participates as an integral part of ganglioside structure in synaptogenesis and neural transmission. Human milk also contains a high concentration of sialic acid attached to the terminal end of free oligosaccharides, but its metabolic fate and biological role are currently unknown.

Federal government websites often end in. Before sharing sensitive information, make sure you're on a federal government site. The site is secure. NCBI Bookshelf. Essentials of Glycobiology [Internet]. Amanda L. Lewis , Xi Chen , Ronald L. Schnaar , and Ajit Varki.

Sialic

Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Sialic acids are a family of nine-carbon acidic monosaccharides that occur naturally at the end of sugar chains attached to the surfaces of cells and soluble proteins. In the human body, the highest concentration of sialic acid as N -acetylneuraminic acid occurs in the brain where it participates as an integral part of ganglioside structure in synaptogenesis and neural transmission. Human milk also contains a high concentration of sialic acid attached to the terminal end of free oligosaccharides, but its metabolic fate and biological role are currently unknown. An important question is whether the sialic acid in human milk is a conditional nutrient and confers developmental advantages on breast-fed infants compared to those fed infant formula. In this review, we critically discuss the current state of knowledge of the biology and role of sialic acid in human milk and nervous tissue, and the link between sialic acid, breastfeeding and learning behaviour.

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E- and P-selectins Chapter 34 connect with passing neutrophils, which have the complementary sialoglycans on their surface lipids or proteins. Efficiency of Gp immunogens MN- and Argp used in the RV trial conferring protection against HIV were improved by enriching the sialic acid content and lacking N-linked glycosylation sites needed for binding by bN-mAbs []. Sia -binding lectins are also useful for detecting sialoglycans and their linkages in situ and on isolated sialoglycans. Peer review information Nature Chemical Biology thanks Jeffrey Esko, Carlito Lebrilla and the other, anonymous, reviewer s for their contribution to the peer review of this work. Tumor cell hypersialylation has been observed to enable tumor cell to evade recognition by NK cells, thus escaping the immune responses. Many microorganisms, including many pathogens, express sialidases. Humana Press Inc. Regardless of the mechanisms involved, certain sialylated molecules are also specific markers for some cancers and potential ligands for targeted therapies Chapter Reduction of sialic acid O-acetylation in human colonic mucins in the adenoma-carcinoma sequence. They function as ligands for glycan-binding proteins, including animal lectins like selectins and siglecs, viral lectins like hemagglutinins HAs , and bacterial lectins like adhesins and toxins. Trypanosoma cruzi surface mucin TcMuc-e2 expressed on higher eukaryotic cells induces human T cell anergy, which is reversible.

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Sialic acid-specific lectin from Tritrichomonas foetus. The diversity of recognized structures raises the possibility that the RBD and the S protein possesses multiple glycan-binding sites with distinct binding properties. In some bacteria, pathways for Sia biosynthesis and breakdown appear in the same genomes, suggesting that recycling of Sias may also occur in some bacteria. CAS Google Scholar. Play Play. KDN deaminated neuraminic acid : dreamful past and exciting future of the newest member of the sialic acid family. Analysis of the distribution of glycoconjugates in the digestive gland of the bivalve mollusc Mytilus galloprovincialis by conventional and lectin histochemistry. Gil-Serrano A. Corfield A. Published : 23 October Roberts J Chemoreceptor-mediated polymerization and depolymerization of actin in hair bundles of sea anemones.