Stilbene

Federal government websites often end in. The site is secure, stilbene. BoxKuopio, Finland. Numerous studies have highlighted the key roles of oxidative stress and inflammation in stilbene diseases such as obesity, type 2 diabetes, age-related macular degeneration AMDand Alzheimer's disease AD.

Classified as a diarylethene , it features a central ethylene moiety with one phenyl group substituent on each end of the carbon—carbon double bond. It has an E stereochemistry, meaning that the phenyl groups are located on opposite sides of the double bond, the opposite of its geometric isomer , cis -stilbene. Trans -stilbene occurs as a white crystalline solid at room temperature and is highly soluble in organic solvents. It can be converted to cis -stilbene photochemically , and further reacted to produce phenanthrene. Stilbene was discovered in by the French chemist Auguste Laurent. Stilbene exists as two possible stereoisomers.

Stilbene

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Stilbene I. In rodents, this compound has been shown to suppress endotoxin induced ocular inflammation [ ] as well as Toll-like receptor 4 TLR4 mediated inflammatory response and retinal damage occurring after retinal ischemia [ ], stilbene.

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Federal government websites often end in. The site is secure. Stilbenes are polyphenolic allelochemicals synthesized by plants, especially grapes, peanuts, rhubarb, berries, etc. They are now exploited in medicine for their antioxidant, anti-proliferative and anti-inflammatory properties. It is characterized by the release of cytokines which can wreak havoc on healthy tissues, worsening the disease condition. Resveratrol, the most studied stilbene, lowers the Michaelis constant of SIRT1, and occupies the substrate binding pocket.

Stilbene

Stilbenes are a class of phenolic metabolites found in various edible plants, such as grapevine, berries and peanuts. Their bioactivitiy and their potential benefits for human health have been the subject of several studies. Among all identified stilbenes, resveratrol has been particularly studied and results from literature showed that it presents several biological activities, including antioxidant, anti-inflammatory and antiproliferative effects.

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For example, stilbenes are natural phenolic defence compounds occurring in a number of different plant species that possess antimicrobial and antioxidant activities against phytopathogens and ozone or UV stress [ 12 ]. Vin A. However, the current obesity problem indicates clearly that, although lifestyle changes are effective in practice, they are very difficult to achieve. ISBN Zhang X. Kansanen E. Rahvar M. Quantitation of trans-resveratrol and detection of its metabolites in human plasma and urine by high performance liquid chromatography. Resveratrol [ 23 ]. The Journal of Biological Chemistry.

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Caveolin-3 is involved in the protection of resveratrol against high-fat-diet-induced insulin resistance by promoting GLUT4 translocation to the plasma membrane in skeletal muscle of ovariectomized rats. Transcription factor, activator of detoxifying enzymes autoregulation. Soluble and mature amyloid fibrils in drusen deposits. For instance, data from mouse models indicates that the Nrf2 system declines with age subjecting RPE cells to oxidative stress [ ]. However, very few well-planned clinical trials are available which would have provided solid evidence for the health benefits of stilbenes for humans. One sign of this impairment is the accumulation of autophagy receptor p62 in AMD [ 90 ]. Nature Cell Biology. Vin A. Therapeutic potential of resveratrol: the in vivo evidence. The therapeutic potential of stilbene compounds against the most common aging-related diseases is discussed. In Keap1 knockout mouse excessive accumulation of Nrf2 into nucleus stimulates aberrant expression of Nrf2 target genes causing growth retardation and the death of pups soon after birth [ 54 ]. Wallerath T. Despite intensive research and drug development, there is still no effective therapy against AD, and at present preventive approaches are thought to be the best way to address this growing public health problem. PMID