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Background: Paraneoplastic neurologic syndrome PNS represents the remote effects of cancer on the nervous system, euronetwork.

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Arch Neurol. Background Paraneoplastic neurologic syndrome PNS represents the remote effects of cancer on the nervous system. Diagnostic criteria for the syndrome were published by the PNS Euronetwork and form the basis of a database to collect standardized clinical data from patients with PNS. Objectives To analyze various types of PNS, frequent tumor and antibody associations, clinical characteristics of individual syndromes, and possible therapeutic and prognostic strategies. Patients Patients were recruited from January 1, , to December 31, Main Outcome Measures Based on diagnostic criteria published by the PNS Euronetwork consortium, clinical characteristics of classic PNS and several other less well-characterized syndromes associated with cancer were assessed. Results Data from patients were analyzed, representing the largest PNS investigation to date. The findings elucidate the clinical evolution of paraneoplastic cerebellar syndrome according to the onconeural antibodies present, the heterogeneity and prognosis of dysautonomic disorders, and the clinical variability of paraneoplastic limbic encephalitis. Conclusion The study results confirm that PNS influences oncologic patient survival. Tumors are the main cause of death, but some types of PNS such as dysautonomia have a poorer prognosis than malignant neoplasms.

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Background and purpose: To describe the characteristics of patients presenting a paraneoplastic cerebellar degeneration without classical onconeural antibodies seronegative PCD. No significant difference between the clinical characteristics of seronegative and seropositive PCD patients was observed. Yet the frequency of associated tumors was different. Seronegative and seropositive PCD patients with similar tumors had a similar overall survival. Conclusion: The clinical characteristics of seronegative and seropositive PCD are similar but the spectrum of associated tumors is different. The immunological scenario of seronegative PCD seems to be different from that of limbic encephalitis with only few patients harboring anti-neuropile antibodies. Keywords: onconeural antibodies; paraneoplastic cerebellar degeneration.

Arch Neurol. Background Paraneoplastic neurologic syndrome PNS represents the remote effects of cancer on the nervous system. Diagnostic criteria for the syndrome were published by the PNS Euronetwork and form the basis of a database to collect standardized clinical data from patients with PNS. Objectives To analyze various types of PNS, frequent tumor and antibody associations, clinical characteristics of individual syndromes, and possible therapeutic and prognostic strategies. Patients Patients were recruited from January 1, , to December 31, Main Outcome Measures Based on diagnostic criteria published by the PNS Euronetwork consortium, clinical characteristics of classic PNS and several other less well-characterized syndromes associated with cancer were assessed. Results Data from patients were analyzed, representing the largest PNS investigation to date. The findings elucidate the clinical evolution of paraneoplastic cerebellar syndrome according to the onconeural antibodies present, the heterogeneity and prognosis of dysautonomic disorders, and the clinical variability of paraneoplastic limbic encephalitis.

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The lack of extensive clinical and epidemiologic studies on these rare disorders prompted establishment of the PNS Euronetwork by 20 consortium members from 11 European countries. Drafting of the manuscript : Giometto, Grisold, and Vitaliani. This guaranteed uniform comparable data but prevented the addition of new diagnostic criteria such as recently detected antibodies associated with PNS. Save Preferences. Purchase access. There were no reported cases of poliomyositis. X Facebook More LinkedIn. Analyses were performed using commercially available statistical software SAS, version 9. Outcome status was available in patients The findings elucidate the clinical evolution of paraneoplastic cerebellar syndrome according to the onconeural antibodies present, the heterogeneity and prognosis of dysautonomic disorders, and the clinical variability of paraneoplastic limbic encephalitis. Results Data from patients were analyzed, representing the largest PNS investigation to date. Statistical analysis : Bertolini. However, this group did not lend itself to further analysis except for patients with extrapyramidal disorders.

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Dysarthria An additional large number of sensory neuronopathies also had significant motor involvement, and this entity was referred to as sensorimotor neuronopathy. A total of patients with SN were initially seen with subacute onset View Large Download. Dysautonomic PNS is underdiagnosed because it develops in the setting of at least 1 other PNS, which may dominate the presentation and mask the autonomic features. In patients with PCD, the most frequent findings were subacute onset of moderate This guaranteed uniform comparable data but prevented the addition of new diagnostic criteria such as recently detected antibodies associated with PNS. Go to my data extractions. Survival is usually influenced by the oncologic disease, but PNS can cause severe disability and may be fatal. Recommended diagnostic criteria for paraneoplastic neurological syndromes. An additional large number of SNs had significant motor involvement, called sensorimotor neuronopathy. The outcome status was available in The clinical profile of collected syndromes in our study confirms the results of previous studies 9 - 14 but is based on a much larger case series. Therapeutic options.