Sitagliptin maximum dose per day

Januvia sitagliptin is a prescription brand-name medication.

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects. This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.

Sitagliptin maximum dose per day

Objective: In clinical trials, the degree of glucose lowering with sitagliptin has been correlated with the magnitude of dipeptidyl peptidase-4 DPP-4 inhibition over 24 h. However, sitagliptin mg once daily provided numerically greater percent plasma DPP-4 inhibition compared with mg once daily. The purpose of this study was to evaluate whether sitagliptin mg once daily provides greater improvement in glycemic efficacy as assessed by weighted mean glucose WMG over 24 h relative to sitagliptin mg once daily and to relate the percent DPP-4 inhibition achieved with these doses to any between-treatment differences in glycemic efficacy. Each of the treatment periods was 7 days in duration, with day washout periods between treatments. After each treatment period, patients underwent blood sampling at various time points over 24 h to determine h WMG. Plasma DPP-4 activity was assessed at trough, 24 h following dosing on day 7; percent DPP-4 inhibition was corrected for sample assay dilution. Following a planned interim analysis, the study was stopped because the h WMG values were not different between the sitagliptin doses. Furthermore, a significant carryover effect across periods was observed for FPG; thus, efficacy results from period 1 are presented herein. The early termination and the carryover effect described above are limitations to this study. Conclusion: Across sitagliptin doses in this study, the similarity of the h WMG concentrations and the similarity of the corrected DPP-4 inhibition values support prior findings that the maximal glucose-lowering efficacy of sitagliptin is achieved with once-daily dosing of mg. Abstract Objective: In clinical trials, the degree of glucose lowering with sitagliptin has been correlated with the magnitude of dipeptidyl peptidase-4 DPP-4 inhibition over 24 h. Associated data ClinicalTrials.

Take this medicine exactly as directed by your doctor. Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations.

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects. This medicine should come with a Medication Guide. Read and follow these instructions carefully.

Back to Sitagliptin. Your doctor might prescribe a lower dose of 25mg or 50mg a day if you have problems with your kidneys. Take sitagliptin once a day. You can take it at any time, for example, in the morning or in the evening. But try to take it at the same time every day.

Sitagliptin maximum dose per day

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects. This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.

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Thank you for subscribing! You'll probably have to take it for a long time, even for the rest of your life. Take the missed dose as soon as you remember, unless it's nearly time for your next dose. Health Information Policy. Besides learning about dosage, you may want other information about Januvia. You should not take two tablets to make up for the missed dose. Research Faculty. International Business Collaborations. If you often forget doses, it may help to set an alarm to remind you. Mayo Clinic Alumni Association. We link primary sources — including studies, scientific references, and statistics — within each article and also list them in the resources section at the bottom of our articles. Takeaway and helpful resources. How we reviewed this article: Sources.

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Clinical Trials. If your dose is different, do not change it unless your doctor tells you to do so. Contact Us. For a comprehensive look at Januvia, see this article. Financial Assistance Documents — Arizona. To provide you with the most relevant and helpful information, and understand which information is beneficial, we may combine your email and website usage information with other information we have about you. Financial Assistance Documents — Minnesota. The purpose of this study was to evaluate whether sitagliptin mg once daily provides greater improvement in glycemic efficacy as assessed by weighted mean glucose WMG over 24 h relative to sitagliptin mg once daily and to relate the percent DPP-4 inhibition achieved with these doses to any between-treatment differences in glycemic efficacy. Plasma DPP-4 activity was assessed at trough, 24 h following dosing on day 7; percent DPP-4 inhibition was corrected for sample assay dilution. The recommended dosage of Januvia for treating type 2 diabetes is mg once daily. Products and services.