White pill with h49

This medication is a single formulation containing 2 drugs, sulfamethoxazole and trimethoprim. These work by stopping bacterial growth.

If you are a consumer or patient please visit this version. To reduce the development of drug-resistant bacteria and maintain the effectiveness of sulfamethoxazole and trimethoprim tablets and other antibacterial drugs, sulfamethoxazole and trimethoprim tablets should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. Sulfamethoxazole and trimethoprim is a synthetic antibacterial combination product available in DS double strength tablets, each containing mg sulfamethoxazole and mg trimethoprim; in tablets, each containing mg sulfamethoxazole and 80 mg trimethoprim for oral administration. It is a white to off-white, practically odorless, crystalline powder, tasteless compound with a molecular weight of Trimethoprim is 2,4-diamino 3,4,5-trimethoxybenzyl pyrimidine; the molecular formula is C 14 H 18 N 4 O 3. It is a white or cream-colored crystals or crystalline powder with a molecular weight of Inactive ingredients: Docusate sodium, magnesium stearate, pregelatinized starch maize , sodium benzoate, and sodium starch glycolate.

White pill with h49

Sulfamethoxazole and trimethoprim combination is used to treat infections including urinary tract infections, middle ear infections otitis media , bronchitis, traveler's diarrhea, and shigellosis bacillary dysentery. This medicine is also used to prevent or treat Pneumocystis jiroveci pneumonia or Pneumocystis carinii pneumonia PCP , a very serious kind of pneumonia. This type of pneumonia occurs more commonly in patients whose immune systems are not working normally, including cancer patients, transplant patients, and patients with acquired immune deficiency syndrome AIDS. Sulfamethoxazole and trimethoprim combination is an antibiotic. It works by eliminating the bacteria that cause many kinds of infections. This medicine will not work for colds, flu, or other virus infections. In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals.

There may be an increased risk of severe adverse reactions in elderly patients, particularly when complicating conditions exist, e. Thirty percent of the total sulfonamide is excreted as free sulfamethoxazole, with the remaining as N 4 -acetylated metabolite. White pill with h49, other epidemiologic studies did not detect statistically significant associations between sulfamethoxazole and trimethoprim exposure and specific malformations.

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:. Other side effects not listed may also occur in some patients.

Go PRO to access past versions. While there are no large, well-controlled studies on the use of sulfamethoxazole and trimethoprim in pregnant women, Brumfitt and Pursell, in a retrospective study, reported the outcome of pregnancies during which the mother received either placebo or sulfamethoxazole and trimethoprim. The incidence of congenital abnormalities was 4. There were no abnormalities in the 10 children whose mothers received the drug during the first trimester. In a separate survey, Brumfitt and Pursell also found no congenital abnormalities in 35 children whose mothers had received oral sulfamethoxazole and trimethoprim at the time of conception or shortly thereafter. Because sulfamethoxazole and trimethoprim may interfere with folic acid metabolism, sulfamethoxazole and trimethoprim should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Human Data While there are no large prospective, well controlled studies in pregnant women and their babies, some retrospective epidemiologic studies suggest an association between first trimester exposure to sulfamethoxazole and trimethoprim with an increased risk of congenital malformations, particularly neural tube defects, cardiovascular abnormalities, urinary tract defects, oral clefts, and club foot. These studies, however, were limited by the small number of exposed cases and the lack of adjustment for multiple statistical comparisons and confounders. These studies are further limited by recall, selection, and information biases, and by limited generalizability of their findings. Lastly, outcome measures varied between studies, limiting cross-study comparisons.

White pill with h49

If you are a consumer or patient please visit this version. To reduce the development of drug-resistant bacteria and maintain the effectiveness of sulfamethoxazole and trimethoprim tablets and other antibacterial drugs, sulfamethoxazole and trimethoprim tablets should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. Sulfamethoxazole and trimethoprim is a synthetic antibacterial combination product available in DS double strength tablets, each containing mg sulfamethoxazole and mg trimethoprim; in tablets, each containing mg sulfamethoxazole and 80 mg trimethoprim for oral administration.

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Signs and symptoms of overdosage reported with sulfonamides include anorexia, colic, nausea, vomiting, dizziness, headache, drowsiness and unconsciousness. Signs of acute overdosage with trimethoprim include nausea, vomiting, dizziness, headache, mental depression, confusion and bone marrow depression. Prevention and treatment of Pneumocystis pneumonia. Dispense in a tight, light-resistant container as defined in the USP. It is a white or cream-colored crystals or crystalline powder with a molecular weight of Especially tell your doctor if you:. Take this medicine exactly as directed by your doctor. Clinical signs, such as rash, pharyngitis, fever, arthralgia, cough, chest pain, dyspnea, pallor, purpura or jaundice may be early indications of serious reactions. In vitro studies suggest that trimethoprim is a substrate of P-glycoprotein, OCT1 and OCT2, and that sulfamethoxazole is not a substrate of P-glycoprotein. Body Surface Area Dose-every 12 hours m 2 Tablets 0. Cough, shortness of breath, and pulmonary infiltrates are hypersensitivity reactions of the respiratory tract that have been reported in association with sulfonamide treatment. Financial Services. Drink plenty of fluids with this medication. Sulfamethoxazole is an inhibitor of CYP2C9. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Sulfamethoxazole and trimethoprim combination is used to treat infections including urinary tract infections, middle ear infections otitis media , bronchitis, traveler's diarrhea, and shigellosis bacillary dysentery. This medicine is also used to prevent or treat Pneumocystis jiroveci pneumonia or Pneumocystis carinii pneumonia PCP , a very serious kind of pneumonia. This type of pneumonia occurs more commonly in patients whose immune systems are not working normally, including cancer patients, transplant patients, and patients with acquired immune deficiency syndrome AIDS.

This may be due to thrombocytopenia, or when your platelet count level drops. The patient should be monitored with blood counts and appropriate blood chemistries, including electrolytes. Aerobic gram-negative bacteria Escherichia coli including susceptible enterotoxigenic strains implicated in traveler's diarrhea Klebsiella species Enterobacter species Haemophilus influenzae Morganella morganii Proteus mirabilis Proteus vulgaris Shigella flexneri Shigella sonnei. Miscellaneous: Weakness, fatigue, insomnia. In vitro studies have shown that bacterial resistance develops more slowly with both sulfamethoxazole and trimethoprim in combination than with either sulfamethoxazole or trimethoprim alone. Thrombocytopenia usually resolves within a week upon discontinuation of sulfamethoxazole and trimethoprim. Adjunctive Treatment with Leucovorin for Pneumocystis jiroveci Pneumonia Treatment failure and excess mortality were observed when trimethoprim-sulfamethoxazole was used concomitantly with leucovorin for the treatment of HIV positive patients with Pneumocystis jiroveci pneumonia in a randomized placebo controlled trial. Sulfamethoxazole and trimethoprim is a synthetic antibacterial combination product available in DS double strength tablets, each containing mg sulfamethoxazole and mg trimethoprim; in tablets, each containing mg sulfamethoxazole and 80 mg trimethoprim for oral administration. Trimethoprim alters the disposition of procainamide and N -acetylprocainamide. Nov ; Suppl : S—S